Depression after quitting smoking
Conditions
Interventions
Control group:An equal amount of saline is sprayed through the nose
Test group:Esketamine 0.5mg/kg
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Both male and female, aged from 18 to 65 years,Lung cancer is diagnosed, surgery for lung cancer is indicated; (2) ASA is classified as grade I~II;(3)Smoking history, 20 per day for 5 years;(4)Hamilton Depression Scale score (HDRS-24) < 35;(5)Voluntarily participate in this treatment and agree to sign the informed consent for relevant treatment.
Exclusion criteria
Exclusion criteria: (1) a history of serious physical or mental illness; (2) Serious risk of elevated blood pressure or intracranial pressure; (3) Patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure exceeding 180/100 MMHG); (4) previous allergy to esketamine; (5) Unable to understand the content of relevant scales; (6) Pregnant women and women trying to get pregnant; (7) Untreated or undertreated patients with hyperthyroidism(8)Patients with severe arrhythmias (tachycardia, ventriculartachycardia, ventricular premature); (9)Subjects who have adverse risk factors deemed unsuitable for the study by the investigator;(10)Subjects who did not want to quit smoking during the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HDRS-24;MADRS;CADSS;BPRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS-D;QIDS-SR16;adverse event; | — |
Countries
China
Contacts
Public ContactWenyuan Wang
Zhejiang Provincial People's Hospital
Outcome results
None listed