Ejaculation Dysfunction
Conditions
Interventions
Healthy Control:Brain functional MRI examination
Lifelong Premature Ejaculation:Brain functional MRI examination + drug therapy
Lifelong Delayed Ejaculation:Brain functional MRI examination + transcranial magnetic stimulation (TMS)
Sponsors
The Second Affiliated Hospital of Anhui Medical of University,
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria of LPE patients:(1) Premature Ejaculation Diagnostic Tool score (PEDT) >11 points; (2) Intravaginal Ejaculatory Latency Time (IELT) <1min, measured by stopwatch; (3) No history of drug treatment. Our age range is 18-45 years old LDE inclusion criteria: (1) meet the diagnostic criteria of DE; (2) PEDT score <5; (3) There is no clear history of drug use or known medical history that may cause DE. Inclusion criteria of healthy control group (HCs) :(1) PEDT score <5; (2) Age, case number, handedness matched with LPE and LDE patients; (3) no history of drug use; (4) Healthy body, no other underlying diseases
Exclusion criteria
Exclusion criteria: Exclusion criteria for all subjects (including LPE, LDE patients and HCs) :(1) International Index of Erectile Function (IEF) <21; (2) a history of alcohol or drug abuse; (3) having a history of mental or neurological diseases; (4) History of head trauma or any contraindications to MRI scans; In addition, all participants were asked to complete the Hamilton Depression Scale (HAMD Scale), the Health Questionnaire Depression Scale (PHQ-9), and the Health Questionnaire Generalized Anxiety Disorder Scale GAD-7 as required by the study to investigate and assess the mental status of all participants. Inclusion criteria of healthy control group (HCs) :(1) PEDT score <5; (2) Age, case number, handedness matched with LPE and LDE patients; (3) no history of drug use; (4) Healthy body, no other underlying diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional connectivity differences in resting brain regions;White matter microstructure of the brain;Brain regions that are activated or suppressed in task state; | — |
Secondary
| Measure | Time frame |
|---|---|
| four Sex hormones;PEDT;CIPE Scale;HAMD Scale;PHQ-9;GAD-7; | — |
Countries
China
Contacts
Public ContactCi Zou
The Second Affiliated Hospital of Anhui Medical University
Outcome results
None listed