lidocaine Effects on neutrophil extracellular trapping and angiogenesis biomarkers in postoperative breast cancer patients with different anesthesia methods

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300068563

Enrollment

Unknown

Registered

2023-02-23

Start date

2023-02-23

Completion date

Unknown

Last updated

2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer

Interventions

Sevoflurane anesthesia experimental group:lidocaine

The control group was anesthetized with sevoflurane:saline

Propofol-TIVA anesthesia experimental group:lidocaine

The control group was anesthetized with propofol-TIVA:saline

Eligibility

Sex/Gender

Female

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 18-70 years, ASA physical status I-III, primary or invasive breast cancer without distant metastasis (stage 0-III), with or without axillary lymph node dissection.

Exclusion criteria

Exclusion criteria: Patients who were allergic to study substances, had diabetes, coronary heart disease, chronic inflammatory diseases, neuropsychiatric diseases, could not give informed consent, could not understand the study protocol or refused to participate in the study, and routinely used glucocorticoids or anti-inflammatory drugs.

Design outcomes

Primary

Measure	Time frame
MPO;H3Cit;NE;MMP-9;VEGF-A;	—

Countries

China

Contacts

Public ContactChenxuexin

General Hospital of Ningxia Medical University

chenxuexin2637@163.com+86 951 6743783

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 28, 2026