epithelial ovarian cancer, fallopian tube cancer and primary peritoneal adenocarcinoma
Conditions
Interventions
Sponsors
Mianyang Central Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. Histologically confirmed epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer and recurrence/metastasis after PARPi maintenance therapy; 3. At least one measurable tumor lesion (according to RECIST1.1), but = 1.5 × 10^9/L, HB >= 80 g/L, PLT >= 80 × 10^9/L L; b) liver function is basically normal: TBIL = 50 mL/min; 7. The site of recurrence and metastasis is not within the previous radiation field; 8. Expected survival time >= 3 months; 9. Subjects must give informed consent to the study before the trial, and voluntarily sign a written informed consent form; 10. The subjects can communicate well with the researchers and complete the research in accordance with the research regulations.
Exclusion criteria
Exclusion criteria: 1. Age > 80 years old; 2. Previously received radiation therapy and the surrounding normal tissues and organs cannot tolerate re-radiation; 3. There are serious or uncontrolled systemic diseases (such as severe mental, neurological disease, epilepsy or dementia, unstable or uncompensated respiratory, cardiovascular, liver or kidney disease, severe infection, uncontrolled hypertension , diabetes, active bleeding).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| objective response rate, ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| No chemotherapy interval;Overall survival, OS; | — |
Countries
China
Contacts
Public ContactRong Wu
Mianyang Central Hospital
Outcome results
None listed