coronary artery disease
Conditions
Interventions
Group A:ciprofol 0.2 mg/kg
Group B:ciprofol 0.3 mg/kg
Group C:etomidate 0.2 mg/kg
Sponsors
General Hospital of Northern Theater Command
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Above 18 years old; 2. ASA score ?-?; 3. BMI 18-30 kg/m2; 4. Patients who plan to undergo elective off-cardiopulmonary bypass grafting.
Exclusion criteria
Exclusion criteria: 1. NYHA cardiac function class IV, or patients with left ventricular ejection fraction (LVEF) < 40%; 2. Patients with preoperative hemodynamic instability, emergency surgery and secondary surgery; 3. Patients with difficult airway, modified Mallampati grade IV patients; 4. Hepatic and renal insufficiency; 5. Nervous or mental disorders, epilepsy; 6. Those who are known to be allergic to active ingredients or excipients of cyclopofol or propofol injection; 7. Drug or alcohol abuse; 8. Patients who are pregnant or breastfeeding; patients who plan to become pregnant within 1 month after surgery; 9. In addition to the primary disease, patients with obvious abnormal results of preoperative physical examination or laboratory examination; 10. Patients who refuse to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the area under the curve below baseline MAP (MAP-time integral); | — |
Secondary
| Measure | Time frame |
|---|---|
| change of CI and SVV;The maximum decrease in MAP;Minimum mean arterial pressure, MAPmin;Heart rate variation;change of BIS value;Incidence of adverse reactions;Anesthesiologists' satisfaction;the use of vasopressors; | — |
Countries
China
Contacts
Public ContactYugang Diao
General Hospital of Northern Theater Command
Outcome results
None listed