Stroke
Conditions
Interventions
TA group:Tegrelol combined with aspirin
LA group:Clopidogrel combined with aspirin
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. 40 <= age <= 70; 2. Patients with acute ischemic cerebrovascular disease within 24 hours of onset; 3. NIHSSS <= 5 in patients with cerebral infarction or ABCD2=4 in patients with TIA; 4. For patients with the first onset or previous cerebral infarction patients without sequelae such as limb paralysis, the NIHSS score will not be affected; the previous mRS score is =1 point; 5 Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Hemorrhagic stroke or mixed stroke; 2. Brain arteriovenous malformation or intracranial tumor; 3. Cardiogenic cerebrovascular disease (including but not limited to arrhythmia, atrial fibrillation, heart valve disease); 4. Patients with uncontrollable severe hypertension, severe infection or abnormal liver function, renal insufficiency, blood system diseases with bleeding tendency, etc.; 5. History of previous cerebral hemorrhage; 6. Retinal hemorrhage or visceral hemorrhage within 30 days; 7. Patients who took ticagrelor 3 months before the onset; 8. Patients with disturbance of consciousness; 9. Patients who are allergic to any component of aspirin, clopidogrel or ticagrelor; 10. Pregnant or lactating women; 11. Those who are considered by the researchers to be inappropriate to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of early neurological deterioration; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS score improvement (30 days, 90 days);30 days, 90 days mRS score;Occurrence of hemorrhagic events;Blood biochemical indicators; | — |
Countries
China
Contacts
Public ContactXiaofei Ji
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed