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The mechanism of modulating visceral pain in IBD through Glu/GABA imbalance and alterations of functional connectivity in the anterior cingulate cortex

The mechanism of modulating visceral pain in IBD through Glu/GABA imbalance and alterations of functional connectivity in the anterior cingulate cortex

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300068506
Enrollment
Unknown
Registered
2023-02-21
Start date
2020-12-01
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's Disease

Interventions

Group 1:none
Group 2:none

Sponsors

The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Case inclusion criteria: (1) Crohn's disease confirmed by endoscopy or pathology; (2) Right-handed; (3) 18-60 years old; (4) Receive more than 9 years of education; 2. Inclusion criteria for healthy controls: (1) Gastrointestinal diseases were ruled out by a gastroenterologist; (2) Right-handed; (3) 18-60 years old; (4) Receive more than 9 years of education.

Exclusion criteria

Exclusion criteria: 1. Those with a history of mental and nervous system diseases, a history of head trauma, and lack of consciousness; 2. Those who have used opiates, hormones, and psychotropic drugs within 3 months; 3. Those with claustrophobia; 4. People with metal implants in the body; 5. Women who are menstruating, lactating, or pregnant.

Design outcomes

Primary

MeasureTime frame
Resting-state functional magnetic resonance imaging;Magnetic resonance spectroscopy;

Secondary

MeasureTime frame
Visual analogue scale;Hospital anxiety and depression scale;Harvey Bradshaw Index;

Countries

China

Contacts

Public ContactMaosheng Xu

The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)

koney1996@163.com+86 150 5817 6932

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026