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The reasearch of immune response to COVID-19 vaccine with gut microbiota in the elderly

Analysis of correlation between immune reactivity and gut microbiota and metabolomics in the elderly after COVID-19 vaccination

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300068490
Enrollment
Unknown
Registered
2023-02-21
Start date
2023-03-01
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immune response to COVID-19 vaccine

Interventions

Case series:N/A

Sponsors

The Second Hospital of Hebei Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria 1. Elderly people aged 65-80,with no history of COVID-19 infection. 2. Any antibiotics, probiotics, prebiotics or other nutritional products have not been applied within 1 month before registration. 3. Those who have been vaccinated according to the COVID-19 vaccination procedure and are eligible for the next dose of the same type of vaccination..

Exclusion criteria

Exclusion criteria: Exclusion criteria 1. History of gastrointestinal surgery. 2. Lactose intolerancce. 3. Immune dysfunction 4. Application of immunosuppressive drugs. 5. Diarrhea is occurring. 6. Severe constipation(50g/l) Exit criteria 1. Adverse reactions such as headache, fever, and cough occur after vaccination; 2. Allergy to any component in the vaccine; 3. Failure to collect venous blood and stool at the time specified in the informed consent form or insufficient sample size. 4. Loss to follow-up.

Design outcomes

Primary

MeasureTime frame
the difference microbiota and small molecular substances;neutralization antibody;Function of T cell;—

Countries

China

Contacts

Public ContactFeng Zhijie

The Second Hospital of Hebei Medical University

zhijiefeng2005@163.com+86 158 0321 0958

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026