respiratory failure
Conditions
Interventions
probiotic group:Bifico
control group:conventional treatment
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients (>= 18 years old); 2. The estimated mechanical ventilation time is more than 72 hours.
Exclusion criteria
Exclusion criteria: 1. Mechanical ventilation time < 5 days; 2. Immunosuppression (HIV, chronic immunosuppressive drugs, previous organ or blood transplantation, absolute neutrophil count<500 cells/ µl); 3. Have a history of factors that increase blood borne infection (rheumatic heart disease, congenital heart disease, mechanical valve, endocarditis, intravascular graft or permanent intravascular devices such as hemodialysis catheter, pacemaker or defibrillator); 4. Enteral nutrition cannot be or is contraindicated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mechanical ventilation time;28-day survival;Pulmonary flora a Shannon index of diversity;Intestinal flora a Shannon index of diversity;Sample comparison analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-1ß;IL-6;IL-8;IL-17A; | — |
Countries
China
Contacts
Public ContactLu Peng; Zhao Heling
The First Hospital of Hebei Medical University; Hebei General Hospital
Outcome results
None listed