postoperative cognitive dysfunction
Conditions
Interventions
Group M:Melatonin was given 30 minutes before bedtime and 30 minutes before anesthesia the day before operation
Group C:Placebo was given 30 minutes before bedtime and 30 minutes before anesthesia the day before operation
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 60 years or older, regardless of gender; 2. Patients classified as ASA grade II to III; 3. Patients who undergo elective laparoscopic surgery for gastrointestinal tumors.
Exclusion criteria
Exclusion criteria: 1. Not having signed an informed consent form; 2. Preoperative Mini-mental State Examination (MMSE) score lower than the lower limit of the corresponding cultural level (illiterate 177µmol/L) or active liver disease; 5. Currently taking sedatives, psychotropic drugs, or melatonin, or having a history of alcoholism; 6. Severe visual or hearing impairment; 7. Routine shift workers; 8. Patients with gastrointestinal tumors accompanied by obstruction; 9. Patients in the acute phase of infection or with systemic autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, inflammatory myopathy, systemic sclerosis, systemic vasculitis, and so on.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;Inflammatory factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain level; | — |
Countries
China
Contacts
Public ContactMin Jia
The First Affiliated Hospital of Nanchang University
Outcome results
None listed