papillary carcinoma of thyroid isthmus
Conditions
Interventions
Experimental group:thyroid isthmus + bilateral intra-lobar 1/3 resection + bilateral central lymph node dissection
Control group:total thyroidectomy plus bilateral central lymph node dissection
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. All PTCI patients aged 18-70 years old who were diagnosed or suspected by FNA cytology or histology before operation (confirmed by postoperative pathology as PTC) [in this study, the researchers drew two virtual lines perpendicular to the skin along the edges of the trachea, taking the intersection of the longest diameter and the shortest diameter of the lesion as the tumor center. If the tumor center of PTC is located between two dotted lines, it is considered to be PTCI. A virtual line perpendicular to the skin was drawn along the middle of the trachea, and the PTCI was divided into left PTCI (PTCIL), right PTCI (PTCIR) and median PTCI (PTCIC); 2. PTCI patients with tumor diameter <= 2cm (T1) and without any clinical evidence of lymph node metastasis (cN0); 3. Before entering the group, the results of laboratory examination were in accordance with the operation conditions, and there were no operative contraindications; 4. There are no psychological, family, social or geographical factors that may affect program compliance and follow-up time; 5. Voluntarily participate, sign informed consent, and be willing to follow up for a long time.
Exclusion criteria
Exclusion criteria: Patients with one of the following conditions may not be included in clinical trials: 1. Preoperative fine or thick needle puncture indicates non-PTC patients; 2. History of thyroid or parathyroid surgery, or other neck surgery; 3. History of radioactive iodine therapy; 4. History of external radiation in the neck; 5. Abnormal preoperative parathyroid hormone or serum calcium levels; 6. Dysfunction of liver, kidney, and other organs; 7. Pregnant and lactating women (excluded by routine urinary pregnancy test in female patients); 8. Those who cannot tolerate surgery for various reasons; 9. Those whose baseline data cannot be fully collected; 10. Other PTC patients who are not PTCI; 11. Those who are considered by researchers to be unsuitable for enrollment; 12. Subjects have poor compliance and are reluctant to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative complication;Tumor recurrence rate;L-T4 dosage;Long-term quality of life; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of surgery;Number of lymph node dissection;Postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactAnping Su
West China Hospital, Sichuan University
Outcome results
None listed