fatty liver disease
Conditions
Interventions
Health group:No
Overweight/obese group of MAFLD patients :No
A lean/normal-weight group of MAFLD patients with metabolic dysfunction:No
MAFLD patients with type 2 diabetes:No
Sponsors
Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Voluntary signing of informed consent; 2. Age 18-70 years old, gender unlimited; 3. The subject is willing to collect and send samples in strict accordance with the sampling procedures; 4. Vital signs, physical examination, blood routine, blood biochemistry and urine routine were all within the normal range or abnormal but considered meaningless by researchers; body mass index (BMI) was 19.0-23.0kg/m^2 (including the boundary value, calculated by formula = weight/height^2); waist circumference = 23kg/m^2; (2) History of type 2 diabetes mellitus or fasting blood glucose >=7.0mmol/L; (3) Metabolic dysfunction, with at least the following two risk factors for metabolic abnormalities: 1) Waist circumference: Asian men and women >=90 and 80cm, respectively; 2) Blood pressure: >=130/85mmHg or receiving blood pressure lowering drugs; 3) Blood triglycerides: >=150mg/dL (>=1.70mmol/L) or receive treatment with lipid-lowering drugs; 4) Plasma HDL cholesterol: =2.5; 7) Blood hypersensitive C-reactive protein: >2mg/L;
Exclusion criteria
Exclusion criteria: 1. Accompanied by chronic diseases that may interfere with the study data, including but not limited to chronic infections, any intestinal diseases or symptoms (including but not limited to constipation, diarrhea and other symptoms, colitis, Crohn's disease, intestinal obstruction, intestinal tumors, etc.); 2. Severe acute illness occurred within 1 month prior to screening that may interfere with the study data; 3. Cirrhosis of the liver; 4. Subjects deemed unsuitable for the study by the researcher, such as poor spirits and poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota;Microbial metabolites; | — |
Countries
China
Contacts
Public ContactXiong Zhifan
Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed