Rosacea
Conditions
Interventions
Rosacea group:N/A
Healthy control group:N/A
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Experiment group: 1. Patients diagnosed with rosacea confirmed the National Board of Rosacea Specialists diagnostic criteria (2017 edition); diagnosed by two senior dermatologists; history of disease longer than 1 year; 2. Aged 18-60 years; 3. Right-handedness; 4. No contraindications to fMRI examination (metal implants, claustrophobia, etc.); 5. No combined serious primary diseases of the heart, brain, liver, kidney, hematopoietic system or neurological or psychiatric diseases; 6. Signed informed consent form. Control group: 1. There was no history of rosacea and related symptoms; 2. Aged 18-60 years; 3. Open your right hand; 4. No contraindications of fMRI examination (metal implantation, claustrophobia, etc.); 5. No serious primary diseases of the heart, brain, liver, kidney or hematopoietic system, or neurological or mental diseases are involved; 6. Voluntarily participate and sign the informed consent.
Exclusion criteria
Exclusion criteria: Experiment group: 1. Have taken pesticides, poisons or other substances that may cause damage to the central nervous system, have a history of alcohol and drug abuse; 2. Have taken antidepressants or other psychiatric drugs on their own; 3. Who have taken non-psychiatric oral medications such as minocycline, pregabalin, carvedilol, etc. orally within 2 weeks; 4. Patients who are pregnant or breastfeeding. Control group: 1. Pregnant and lactating patients; 2. Serious asymmetry of skull anatomy or clear lesions found in the scan; 3. Unconsciousness, unable to express discomfort independently or unable to cooperate with the completion of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| functional connectivity;Trait anxiety;depressive score; | — |
Secondary
| Measure | Time frame |
|---|---|
| amplitude of low-frequency fluctuation;gray matter volume;Scores of The Big-Five;Stigma questionnaire;Resilience Scale;Cognitive Emotion Regulation Questionnaire;Dermatology Quality of Life questionnaire;Social Appearance Anxiety Scale;Social Avoidance and Distress Scale; | — |
Countries
China
Contacts
Public ContactJiang Xian
West China Hospital, Sichuan University
Outcome results
None listed