Hepatic occupancy
Conditions
Interventions
Group P:propofol
Group R1:Remimazolam 0.2mg/kg/h combined with propofol
Group R12:Remimazolam 0.1mg/kg/h combined with propofol
Sponsors
Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Subjects scheduled for hepatobiliary surgery; (2) Age 18 ~ 65 years old, regardless of gender; (3) The American Society of anesthesiologists (ASA) was classified as grade I, II and III; (4) Body mass index (BMI) 18-28kg/m2; (5) The estimated operation time should not exceed 6h; (6) Voluntary participation and signed informed consent
Exclusion criteria
Exclusion criteria: (1) Patients with severe organ dysfunction, such as heart, lung, brain, kidney and other serious diseases; (2) Patients with cognitive impairment or history of mental illness who cannot cooperate with researchers; (3) Long term use of sedative or analgesic drugs, opioid dependence or tolerance, and drug abuse history; (4) Have a history of allergy or contraindications to the anesthetics used; (5) Patients with history of PONV and major problems in previous anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recovery time;Ricker sedation agitation score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to improve Aldrete score to 9;Extubation time;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactWang Zhongyu
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed