primary immune thrombocytopenia
Conditions
Interventions
Group 1:Hydroxychloroquine and prednisone
Group 2:prednisone
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) 18-70 years old, male or female; (2) Newly diagnosed primary ITP; (3) Platelet count =30×109/L or platelet count <50×109/L accompanied with bleeding symptoms; (4) Be able to understand the procedures and methods of this study, sign the informed consent voluntarily and strictly abide by the clinical trial protocol; (5) Subjects agree to use effective contraceptive measures during the trial period and for 6 months after the end of the last medication.
Exclusion criteria
Exclusion criteria: (1) Secondary ITP; (2) Pregnancy or lactation; (3) hypersensitivity to glucocorticoid or hydroxychloroquine; (4) Hepatitis B,Cor HIV infection; (5) Contraindication of glucocorticoid: such as diabetes, poorly controlled hypertension, glaucoma, active gastrointestinal ulcer, severe osteoporosis, active tuberculosis or other uncontrolled diseases, etc.; (6) Contraindications of hydroxychloroquine: macular degeneration of fundus; (7) severe mental illness or epilepsy; (8) Other Conditions that researchers consider unsuitable for participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sustained response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Initial response rate ;Time to response;Duration of reaction; | — |
Countries
China
Contacts
Public ContactBi Hui
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed