asthenospermia
Conditions
Interventions
Treatment group:Shen Hai Long Capsule
Control group:Shengjing Capsule
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
Male
Age
22 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) Age range from 22 to 50 years old; (2) Patients with mild to moderate asthenospermia, that is, at least two normative semen analyses indicated that 10%=PR percentage < 32% and the total number of PR sperm ranged from 5 million to 20 million; (3) At least two standard semen analyses indicated that sperm concentration =15×106 /ml; Sperm normal morphology rate =4%; (4) No other Chinese and Western drugs for the treatment of oligospermia, weak and malformed spermia have been taken in the past 3 months; (5) The subject voluntarily participates and signs the informed consent.
Exclusion criteria
Exclusion criteria: (1) Varicocele, ejaculatory duct/seminal vesicle cyst, anti-sperm antibody (+); (2) Genital tract infection: seminal plasmic elastase > 1000ng/ml or leukocyte semen disease (peroxidase positive cell concentration in semen more than 1×10^6/mL); (3) Erectile dysfunction, ejaculation disorders; (4) suffer from mental disorders, immune system diseases; Severe impairment of liver and kidney function (serum transaminase =2× upper limit of medical reference value, creatinine clearance =40ml/min or active stage of chronic kidney disease); (5) Patients with allergic history or constitution to therapeutic drugs; (6) Patients who have taken drugs affecting the study within 3 months, such as antitumor and antiepileptic drugs, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Forward motile sperm ratio (PR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Sperm survival rate;Sperm concentration;Normal morphology rate of sperm;Seminal malondialdehyde (MDA);Seminal superoxide dismutase (SOD); | — |
Countries
China
Contacts
Public ContactYuanzhen ZHANG
Zhongnan Hospital of Wuhan University
Outcome results
None listed