Pulmonary Nodules at High Risk of Lung Cancer
Conditions
Interventions
experimental group:Oral Yiqi Yangyin Jiedu Decotion (YQYYJD)
control group:none
Sponsors
Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients with stage I lung cancer who met the diagnostic criteria of primary lung cancer and were confirmed by histopathology or cytology included adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma and large cell carcinoma; (2) ground glass nodule (GGN) was found on CT scan, which indicated that it was adenocarcinoma in situ (AIS) or minimally invasive adenocarcinoma (MIA) (mainly judged by size and density), with an average diameter of > 6 Mm, generally not exceeding 12mm, or CT scan revealed clear nodules of the same type before operation, mainly with ground glass nodules (solid nodules need more strict diagnosis and exclusion); (3) syndrome differentiation of Qi and yin deficiency by TCM; (4) 6 months or more after untreated or previous inhalation of budesonide; (5) heart, liver, kidney and blood tests were all in normal range. (6) Sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with other primary malignant tumors; (2) Patients with serious heart, liver and kidney diseases and severe functional disorders; (3) Pregnant or lactating women; (4) Mental or cognitive disorders that affect the judgment of this study; (5) Those who are participating in other drug trials; (6) Those who are allergic to the drugs in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GGO disease control rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Cell free DNA (TP53, EGFR, PIK3CA);TAAB(p53?PGP9.5?SOX2?GAGE7?GBU4-5?CAGE?MAGE A);Tumor markers;immune function markers;quality of life (QOL); | — |
Countries
China
Contacts
Public ContactGuangxin Ruan
Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed