metabolic disorders
Conditions
Interventions
Group of Ciprofol:The use of Ciprofol during anesthesia induction and maintenance period
Group of propofol:The use of propofol during anesthesia induction and maintenance period
Sponsors
the First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: ( 1 ) Age : 18-60 years ; ( 2 ) Obese patients : body mass index ( BMI ) > 30 kg / m2 ; ( 3 ) ASA grade I ~ II ; ( 4 ) Patients scheduled for elective laparoscopic sleeve gastrectomy under general anesthesia.
Exclusion criteria
Exclusion criteria: ( 1 ) Patients with cardiovascular, respiratory or renal diseases and cortical dysfunction with clinical significance ; ( 2 ) Patients with other expected intubation difficulties and expected difficult airway factors except obesity ; ( 3 ) patients known to be allergic to eggs, soy products or propofol, and patients with contraindications to propofol, opioids and their relievers ; ( 4 ) pregnant and lactating women ; ( 5 ) Family history of malignant hyperthermia ; ( 6 ) patients undergoing general anesthesia within 4 weeks during perioperative period ; ( 7 ) Patients with alcohol or drug abuse within 3 months of perioperative period ; patients who had taken drugs that may affect the QT interval or induce / inhibit P450 or CYP2B6 within 2 weeks of the perioperative period ; ( 8 ) Preoperative examination : QTc interval = 450ms in ECG screening ; personnel with abnormal laboratory measurement results related to cardiopulmonary system during screening ; ( 9 ) Have taken sedatives / anesthetics within 3 days after screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean arterial blood pressure;Heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral capillary oxygen saturation;Anesthetic dosage;sedation scale;score pain;incidence of adverse events; | — |
Countries
CHINA
Contacts
Public ContactLI YA LAN
Outcome results
None listed