Effect of permissive hypercapnia on local cerebral oxygen saturation and optic nerve sheath diameter in patients undergoing robotic surgery for gynecologic tumors

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300068303

Enrollment

Unknown

Registered

2023-02-14

Start date

2023-02-20

Completion date

Unknown

Last updated

2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uterine-related diseases

Interventions

Permissive hypercapnia group:Adjust the ventilation parameters, adjust the respiratory rate, I: E=I: 2, Fi02 60%, and maintain the PaCO2 from 46 to 55 mmHg

control group:Adjust the ventilation parameters, adjust the respiratory rate, I: E=I: 2, Fi02 60%, and maintain the PaCO2 from 35 to 45 mmHg

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients with gynecologic tumors planned for robotic surgery, aged between 19 and 65 years, and classified as anesthesia grade I or II, were selected

Exclusion criteria

Exclusion criteria: Patients with congestive heart failure, obstructive coronary artery disease, uncontrolled hypertension, uncontrolled diabetes mellitus, cerebrovascular disease, previous cerebral hemorrhage or trauma, active lung infection, obstructive or interstitial lung disease, glaucoma, previous ophthalmic surgery, body mass index greater than 25 kg/m2, hemoglobin <90g / l

Design outcomes

Primary

Measure	Time frame
rSO2;	—

Secondary

Measure	Time frame
The diameter of the optic nerve sheath;	—

Countries

China

Contacts

Public Contactshanreai

First Affiliated Hospital Of Gannan Medical University

shanreai@163.com13803587468

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026