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Expression of AQP3, AQP1 and HIF-1? in appendiceal tissues of patients with acute and chronic appendicitis and their influence on the diagnostic value of appendicitis and intestinal mucosal function

Expression of AQP3, AQP1 and HIF-1? in appendiceal tissues of patients with acute and chronic appendicitis and their influence on the diagnostic value of appendicitis and intestinal mucosal function

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300068277
Enrollment
Unknown
Registered
2023-02-13
Start date
2023-02-15
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute and chronic appendicitis

Interventions

acute and chronic appendicitis group:N/A

Sponsors

Shaoxing People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Appendectomy was performed under general anesthesia. The patient was diagnosed as appendicitis by pathological diagnosis, with ASA classification of I-II, age of 18-80 years, gender unlimited, and body mass index of 18-25.

Exclusion criteria

Exclusion criteria: Accompanied by diabetes, autoimmune diseases, cancer, blood diseases, pregnant women, lactating women, etc.

Design outcomes

Primary

MeasureTime frame
Expression of AQP1 and AQP3 in appendix tissue;Expression of HIF-1? and GLUT1 in appendix tissue;Expression of TJS protein in appendix (ZO-1, Claudin-1 and Cccludin);Plasma inflammatory and oxidative stress indicators: IL-6, TNF-?, CRP, SOD and MDA;Plasma intestinal mucosal permeability indexes: LPS, SCD1, DAO, FABP2;—

Countries

China

Contacts

Public ContactLi Yuhong

Shaoxing People's Hospital

yuh_li@qq.com+86 13758147990

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026