nonalcoholic fatty liver disease
Conditions
Interventions
Gold Standard:Histopathology of the liver
Index test:Elastic ultrasound, serological indicators of glucose and lipid metabolism, a2 macroglobulin, hyaluronic acid, CK-18
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 16-65 years old, gender is not limited; 2. Comply with the indications for bariatric surgery in the "Guidelines for Surgical Treatment of Obesity and Type 2 Diabetes in China (2019 Edition)" and plan to undergo bariatric surgery; 3. Previous or preoperative physical examination, laboratory tests, and imaging examinations suggest fatty liver.
Exclusion criteria
Exclusion criteria: 1. There are surgical contraindications; 2. Alcohol drinking history: long-term drinking history, generally more than 5 years, the equivalent ethanol amount is >= 30 g/d for men and >= 20 g/d for women; or has a history of heavy drinking within 2 weeks, and the equivalent ethanol amount > 80 g/d; 3. Hepatolenticular degeneration, hepatitis C, abeta lipoproteinemia, Reye syndrome, HELLP syndrome, inherited metabolic diseases and other possible causes of hepatic steatosis; 4. Taking amiodarone, methotrexate, tamoxifen, glucocorticoids, sodium valproate, HIV antiretroviral drugs; 5. People with mental disorders, cognitive dysfunction, and those who cannot express their wishes correctly; 6. Diagnosed or suspected malignant tumors; 7. People with hepatitis B virus and hepatitis C virus infection; 8. HIV-infected persons; 9. Severe coagulation dysfunction or thrombocytopenia; 10. There are other serious diseases that affect the evaluation of this study at the same time, and those who cannot cooperate; 11. Cannot understand the procedures and methods of this clinical study, refuse to participate and refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| nonalcoholic fatty liver activity score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stages of liver fibrosis; | — |
Countries
China
Contacts
Public ContactQiyuan Yao
Huashan Hospital, Fudan University
Outcome results
None listed