Capillary leakage syndrome
Conditions
Interventions
control group:The delayed initiation of CBP strategy group was given the basic treatment of CLS, but when the existing treatment failed, that is, CBP therapy was initiated when the following condition
Experimental group:n the early initiation of CBP strategy group, once CLS was diagnosed, CBP therapy was initiated under the original basic treatment regimen
Sponsors
Jiangxi Maternal and Child Health Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged = 1000 g, <= 2000 g; 3. It meets the diagnostic criteria of neonatal capillary leakage syndrome. Diagnostic criteria for CLS: The diagnosis is mainly based on clinical manifestations, that is, the existence of definite inducing factors (different from systemic CLS without definite inducing factors); Physical examination: body mass increased by more than 3% within 24 h, systemic skin mucosal edema, bulbar conjunctival edema, blood pressure and central venous pressure decreased, or accompanied by pleuroperitoneal effusion and pericardial effusion; Laboratory examination: hypoproteinemia (< 25 g/L), edema aggravated after supplementing small molecule crystal substance, increased blood concentration or hematocrit (HCT), urine trace protein positive, decreased blood-oxygen binding ability, X-ray showed exudative changes in lung interstitium.
Exclusion criteria
Exclusion criteria: 1. Cardiogenic, nephrogenic, hepatogenic edema, genetic metabolic diseases, and congenital malformations (such as complex congenital heart disease or congenital heart disease with severe hemodynamic changes, chromosome abnormalities, fetal edema, etc.); 2. There are other serious life threatening complications: pulmonary hemorrhage, grade 3-4 intracranial hemorrhage, severe pulmonary hypertension (reaching the guideline for the application of ECMO).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mental state;Skin temperature;Skin color;Capillary refill time;Blood pressure;Changes in pulse rate;Shock index;Changes in urine volume;Central venous pressure;Cardiac index;Blood gas analysis;Blood lactic acid;Coagulation function;Serum creatinine;Urea nitrogen;Duration of hypotension;Duration of edema;Duration of oliguria;The duration of vasoactive drug use; | — |
Secondary
| Measure | Time frame |
|---|---|
| The duration of the ventilator;Time to start enteral feeding;Survival rate;complication; | — |
Countries
China
Contacts
Public ContactLi Xu
Jiangxi Maternal and Child Health Hospital
Outcome results
None listed