POCD
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged 65-75 years, ASA I-II level; 2. To general anesthesia downlink elective gastrointestinal surgery, the surgery is expected time 2-4 h, the expected length of hospital stay for 7 days or more; 3. Preoperative MMSE score > 20 points (primary school education), or 24 points > (high school/technical school or above degree).
Exclusion criteria
Exclusion criteria: 1. Preoperative depression, cognitive impairments; 2. Drugs and alcohol or long-term use of benzodiazepines drugs, antidepressants; 3. Hearing or visual impairment; 4. Every cerebrovascular accident within half a year, or combined with neurological sequelae; 5. The history of cardiovascular or central nervous system operation; 6. Physical defect or limb skin defect; 7. Emergency surgery; 8. Illiterate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory speech learning test;Trail making test;Clock drawing test;Stroop color word interference test; | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF-a, IL-1ß, IL-6, CRP; | — |
Countries
China
Contacts
The Affiliated Hospital of Medical School of Ningbo University