post-induction hypotension of general anesthesia
Conditions
Interventions
Group A:The blood pressure during post-induction and during operation was controlled within ±10% of the baseline value of preoperative blood pressure
GroupB:The intraoperative blood pressure was controlled within ±10% of the preoperative blood pressure base value, post-induction blood pressure was carried out according to clinical treatment standar
GroupC:The blood pressure during post-induction was controlled within ±10% of the baseline value of preoperative blood pressure, intraoperative blood pressure was carried out according to clinical tre
GroupD:Blood pressure during post-induction and during operation were all carried out according to clinical treatment standards
Sponsors
Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years old, ASA grade I-III; 2. Patients undergoing elective open reduction of hip and lower extremity fractures or hip/knee arthroplasty under general anesthesia with endotracheal intubation; 3. Ethical, patients volunteered to take the test, signed informed consent, and were able to complete the scale test; 4. For Chinese-speaking patients with an expected hospital stay of more than 48 hours, the operation time is between 2 hours and 5 hours; 5. No analgesic or sedative drugs were used the day before surgery; 6. The telephone version of the Montreal Cognitive Assessment (T-MoCA) was used to evaluate the preoperative cognitive status >= 18 points, and the preoperative (3D-CAM) was negative.
Exclusion criteria
Exclusion criteria: 1. Suffering from mental or nervous system diseases or suspected dementia or memory impairment; 2. Severe impairment of hearing, vision and language system function; 3. Critically ill patients (ASA IV or above), severe liver and kidney diseases (Child-Pugh grade C or preoperative dialysis patients), and severe cardiopulmonary and brain diseases; 4. T-MoCA scale, 3D-CAM, and patients with cognitive dysfunction before operation; 5. Identify/suspect abuse or long-term use of narcotic sedative and analgesic drugs; 6. Patients with contraindications or allergies to drugs and anesthetics used during the observation period; 7. Combined with complex injury: multiple fractures, chest, abdomen, pelvis, sacral trauma, head trauma; 8. Relative contraindications of general anesthesia: known difficult airway, malignant high fever, etc.; 9. Patients who participated in other clinical studies during the same period; 10. Patients who plan to be admitted to ICU after surgery; 11. Prisoners in custody; 12. Patients were not eligible for enrollment as determined by the attending physician, attending anesthesiologist, or site clinical director or other designated person.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative agitation;perioperative neurocognitive disorder; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative complications;visual analogue scale score;Quality of sleep;Readmission rate;Total hospital stay;Total hospital costs; | — |
Countries
China
Contacts
Public ContactXiangdong Chen
Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed