vascular cognitive impairment
Conditions
Interventions
Control group:Conventional treatment
rTMS group:Conventional treatment + rTMS
HBOT group:Conventional treatment + HBOT
HBOT combined with rTMS group:rTMS + HBOT
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. A diagnosis of VCI according to the Guidelines for Diagnosis and Treatment of vascular cognitive Impairment in China (V.2019). Having impairment of at least one cognitive domain in executive function, attention, memory, language and visual space, and confirmed by CT or MRI; 2. Aged between 20 and 80 years, and the gender is not limited; 3. The Mini-mental State Examination (MMSE) score <= 26 points, or the Montreal Cognitive Assessment (MoCA) score < 26 points; 4. Education level is primary and above; 5. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Have been suffering from brain tumors, encephalitis, AD, or traumatic brain injury; 2. Vital signs are unstable and the disease progresses rapidly; 3. Having severe impairment of speech, hearing and vision; 4. Be unconsciousness or persistent vegetative state; 5. Having severe mental disorder or obvious depression; 6. Have been suffering from epilepsy, vital organ failure and other diseases which affected the cognitive rating; 7. Having contraindications for rTMS; 8. Having contraindications for HBOT.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum Mental State Examination;Modified Barthel index;Near infrared functional brain imaging; | — |
Countries
China
Contacts
Public ContactHuang Cheng
West China Hospital of Sichuan University
Outcome results
None listed