analgesia after digestive endoscopy
Conditions
Interventions
Group P:intraoperative intravenous administration of acetaminophen
Group C:intraoperative intravenous administration of equal dose of normal saline
Sponsors
Liaocheng People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40-69 years; 2. Endotracheal intubation and inhalation combined with general anesthesia for esophageal ESD; 3. American Association of Anesthesiologists (ASA) classification I-II.
Exclusion criteria
Exclusion criteria: 1. Allergic to paracetamol; 2. Impaired liver function (alanine transaminase and/or aspartate transaminase levels are more than 2 times higher than the upper limit of the normal range, or total bilirubin is greater than or equal to 1.5 times of the upper limit of the normal range); 3. Renal insufficiency (creatinine level >176 µ mol/L); 4. Chronic alcoholism (strong or compulsive desire to drink; physiological withdrawal reaction); 5. Taking opioids for a long time; 6. Mental illness and/or inability to understand VAS score.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale score;incidence of nausea, vomiting and dizziness; | — |
Secondary
| Measure | Time frame |
|---|---|
| visual analogue scale score;white blood cell count at 24h after operation;temperature 24h after operation;incidence rate of postoperative bleeding and perforation complications; | — |
Countries
China
Contacts
Public ContactZhang Zongwang
Liaocheng People's Hospital
Outcome results
None listed