Effects of different doses of dextroketamine pretreatment on the pharmacodynamics of propofol during anesthesia induction in elderly patients

A randomized, double-blind, parallel controlled study to evaluate the pharmacodynamics of propofol during anesthesia induction in elderly patients treated with different doses of esketamine

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300068234

Enrollment

Unknown

Registered

2023-02-10

Start date

2023-02-10

Completion date

Unknown

Last updated

2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with general anesthesia

Interventions

Control group:placebo

group A:0.25 mg/kg esketamine

group B:0.5 mg/kg esketamine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. ASA?~II; 2. Age >= 65 years; 3. BMI was 19-27 kg/m2; 4. During the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan; 5. With self-ability to understand the research procedures, the informed consent & voluntarily sign an informed consent form and be able to comply with the requirements of the clinical study protocol.

Exclusion criteria

Exclusion criteria: 1. Study involves drug allergy; 2. Patients with severe cardiovascular, cerebrovascular, liver, kidney, respiratory diseases; 3. BMI 27 kg/m2; 4. Patients with expected difficult airway; 5. Patients with contraindications to ketamine; 6. Patients who take analgesic or sedative drugs for a long time or are affected by alcohol for a short or long time; 7. Use drugs that affect the central nervous system; 8. Chronic pain patients; 9. Patients who have or have had a history of severe mental disorders; 10. Patients with malignant or poorly controlled hypertension.

Design outcomes

Primary

Measure	Time frame
Propofol EC50;	—

Secondary

Measure	Time frame
Respiratory circulation function;Resuscitation complications;	—

Countries

China

Contacts

Public ContactLonghui Cao

Sun Yat-Sen University Cancer Centre

caolh@sysucc.org.cn+86 20 8734 3063

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026