COVID-19
Conditions
Interventions
Ozonated water enema group:Ozonated water enema
Deionized water enema group:Deionized water enema
Sponsors
Department of Anesthesiology and Pain Mnagement, Shanghai East Hospital, School of Medicine, Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years old, male or female; 2. The diagnostic criteria for severe COVID-19 in adults according to the 2022 diagnosis and treatment Plan for COVID-19 (trial 9th edition) are as follows: (1) 2019-ncov nucleic acid test was positive; (2) Confirmed epidemiological history within 14 days; (3) Clinical manifestations related to COVID-19 such as fever and/or respiratory symptoms; (4) Chest CT has the imaging characteristics of COVID-19; (5) Anyone who meets any of the following: 1) Shortness of breath, RR >= 30 times/min; 2) In the resting state, oxygen saturation during air inhalation was 50%; (6) Critical type meets one of the following conditions: 1) respiratory failure requiring mechanical ventilation; 2) the onset of shock; 3) Complicated with other organ failure requiring ICU care; 3. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Massive blood loss, acute bleeding, anemia (Hb < 90 g/L); 2. Severe coagulopathy or thrombocytopenia less than 50 x 10^9/L; 3. Thalassemia, sickle cell anemia, glucose-6-phosphate dehydrogenase deficiency (patients with faba disease); 4. Toxic diffuse goiter (Graves' disease); 5. Severe unstable cardiovascular disease, acute myocardial infarction; 6. Women who are pregnant or lactating or menstruating; 7. Patients with mental illness, nervous system disease or high sensitivity; 8. Continuous use of immunosuppressants or organ transplantation within the past 6 months; 9. Investigator assessment of subjects unable or unwilling to comply with protocol requirements; 10. Intestinal obstruction, intestinal perforation, acute alcohol poisoning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein;Procalcitonin;28-day survival rate;IL-8;IL-1ß;stool for routine;TNF-a;oxygenation index;Sequential Organ Failure Assessment Score; | — |
Countries
China
Contacts
Public ContactLijun Liao
Department of Anesthesiology and Pain Mnagement, Shanghai East Hospital, School of Medicine, Tongji University
Outcome results
None listed