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Composition and cardioprotective effect of plasma exosomes derived from morphine preconditioning in patients with chronic heart failure

Composition and cardioprotective effect of plasma exosomes derived from morphine preconditioning in patients with chronic heart failure

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300068227
Enrollment
Unknown
Registered
2023-02-10
Start date
2023-02-15
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic heart failure

Interventions

Morphine :morphine, po.
Control:Placebo, po.

Sponsors

The Second Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients with chronic heart failure (Stage C and D) undergoing elective surgery for valve replacement during cardiopulmonary bypass; 2. Aged > 18 years old, male and female; 3. Body mass index (BMI) 18~30 kg/m2; 4. ASA is graded II to IV; 5. Get informed consent from patients and/or their families.

Exclusion criteria

Exclusion criteria: 1. The history of opioids addiction; 2. Patients with cardiomyopathy with unexplained causes; 3. Diabetes and obese patients; 4. Patients with severe mental illness who cannot cooperate; 5. Patients with severe respiratory diseases and liver and kidney failure.

Design outcomes

Primary

MeasureTime frame
Proteomics of exosome;Transcriptomics of exosome;Protein expression;cTnI;—

Secondary

MeasureTime frame
Apoptosis and viability of cardiomyocytes;Echocardiography;Postoperative adverse event;—

Countries

China

Contacts

Public ContactYe Zhang

The Second Hospital of Anhui Medical University

zhangye_hassan@sina.com+86 551 6386 9480

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026