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A multi-center clinical study on the reconstruction of finger extensor function by transposition of the accessory/intercostal nerve combined with free gracilis transplantation

A study on the regulation of peripheral nerves in central limb spastic paralysis

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300068221
Enrollment
Unknown
Registered
2023-02-10
Start date
2023-02-15
Completion date
Unknown
Last updated
2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Central spastic paralysis of upper limbs

Interventions

group 1:T1 nerve root rhizotomy + gracilis transplantation + rehabilitation therapy

Sponsors

Beijing Jishuitan Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 3-50 years old; 2. The history of central spastic paralysis of upper limbs caused by brain trauma and stroke was >= 1 year, and the history of cerebral palsy was >= 3 years; 3. Modified Ashworth Scale hand flexor muscle tone >= 2; 4. MRC grade finger flexor muscle strength >= 3 and finger extensor muscle strength < 2; 5. All joints of the upper limbs had no contracture and fixed stiffness deformity.

Exclusion criteria

Exclusion criteria: 1. Athetosis; 2. Hypertonia due to extrapyramidal system and other lesions; 3. Mental retardation; 4. History of neurotomy; 5. Pulmonary insufficiency; 6. History of rib fracture; 7. Combined with lung diseases (tumor, emphysema, cor pulmonale); 8. Combined with accessory nerve injury; 9. Combined with significant vascular sclerosis.

Design outcomes

Primary

MeasureTime frame
Flexor tone of hand (Modified Ashworth scale);

Secondary

MeasureTime frame
Fugl-Meyer upper limb function score;Modified House functional classification;Muscle strength (MRC grade);pulmonary function;

Countries

China

Contacts

Public ContactWenjun Li

Beijing Jishuitan Hospital

dcliwenjun@163.com+86 139 1045 2661

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026