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Study on the effectiveness of endoscopic flushing with pronase and simethicone to improve lesion detection rate in intractable gastric mucus population

Study on the effectiveness of endoscopic flushing with pronase and simethicone to improve lesion detection rate in intractable gastric mucus population

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300068216
Enrollment
Unknown
Registered
2023-02-10
Start date
2021-08-01
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intractable gastric mucus

Interventions

Intervention group:endoscopic flushing with pronase and simethicone
Control group:endoscopic flushing with warm water

Sponsors

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients of both sexes between 18 and 75 years of age undergoing gastroscopy were included in the study; 2. With gastric mucosal visibility score 3 in 2 or more segments; 3. Patients capable of giving informed consent.

Exclusion criteria

Exclusion criteria: 1. There are contraindications for painless gastroscopy, including severe coronary heart disease and myocardial injury with severe cardiac insufficiency, esophageal stricture or cardiac obstruction, aortic aneurysm, hemorrhagic shock, acute pharyngitis and tonsillitis, pneumonia or other infections with high fever, asthmatic dyspnea, severe pulmonary dysfunction, extremely weak constitution, pregnant women, patients who do not cooperate and psychopath; 2. Allergic reactions to all medications used in this study, including streptomycin granules, simethicone, sodium bicarbonate, propofol; 3. Acute gastrointestinal bleeding; 4. History of upper gastrointestinal tract surgery; 5. Pregnancy or lactation; 6. Refused to participate in this study.

Design outcomes

Primary

MeasureTime frame
lesion detection rate;

Secondary

MeasureTime frame
procedure time;Flushing efficiency;

Countries

China

Contacts

Public ContactZhang Haiyan

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

zhanghaiyan128@126.com+86 138 2448 2735

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026