central precocious puberty
Conditions
Interventions
Group of patients treated with GnRHa:N/A
Group of patients receiving GnRHa combined with rhGH:N/A
Group of patients who did not receive or refused to receive GnRHa treatment:N/A
Sponsors
West China Second University Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of CPP, age 3.4 cm in length, ovarian volume > 1 mL and multiple follicles > 4 mm in diameter in girls; testicular volume >= 4 mL or testicular length diameter > 2.5 cm in boys; 6. Basal serum gonadotropin levels reaching to the levels of puberty with LH > 5.0 IU/L; 7. Serum gonadotropin level reaching to the levels of puberty, with GnRH stimulation test showing peak LH >= 5.0 U/L and peak LH/ peak FSH >= 0.6.
Exclusion criteria
Exclusion criteria: 1. Secondary CPP with a clear etiology, such as central nervous system abnormalities, congenital adrenocortical hyperplasia, McCune-Albright syndrome, primary hypothyroidism, familial male-limited precocious puberty; 2. Those with other conditions related to gonadal function, such as simple premature breast development; 3. Those with a combination of other conditions that may affect height, such as severe malnutrition, growth hormone deficiency, etc.; 4. Those who have been treated in an external hospital; 5. Those who have achieved final height (FH) at the time of first consultation; 6. Those with incomplete data on important covariates.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| final height;final height - initial predicted adult height;final height - target height; | — |
Secondary
| Measure | Time frame |
|---|---|
| final height standard deviation score; | — |
Countries
China
Contacts
Public ContactLingli Zhang
West China Second University Hospital, Sichuan University
Outcome results
None listed