Postoperative Analgesia of Cesarean Section
Conditions
Interventions
DR1 group:0.25 µg/kg dexmedetomidine + 0.25% ropivacaine 40mL
DR2 group:0.50 µg/kg dexmedetomidine + 0.25% ropivacaine 40mL
DR3 group:0.75 µg/kg dexmedetomidine + 0.25% ropivacaine 40mL
DR4:1.00 µg/kg dexmedetomidine + 0.25% ropivacaine 40mL
DR group:0 µg/kg dexmedetomidine + 0.25% ropivacaine 40mL
Sponsors
Panzhihua Central Hospital
Eligibility
Sex/Gender
Female
Age
19 Years to 45 Years
Inclusion criteria
Inclusion criteria: Patients aged 19-45 years, BMI 18-30, normal single pregnancy, gestation >= 37 weeks, ASA grade I-II, combined spinal-epidural anesthesia, able to understand and willing to report pain using the Visual Analogue Score (VAS).
Exclusion criteria
Exclusion criteria: 1. The patient refused; 2. Allergic to drugs (ropivacaine or dexmedetomidine); 3. Systemic or puncture site infection; 4. Abnormal coagulation function; 5. Long-term history of taking opioids, sedatives, antidepressants, and monoamine oxidase inhibitors; 6. High-risk pregnancy (severe diabetes or hypertension, severe liver and kidney dysfunction; heart failure; serious lung diseases; mental or nervous system diseases; obstructive sleep apnea syndrome; severe arrhythmia (especially sinus bradycardia and conduction block); the previous pregnancy had serious complications; other problems that may occur during pregnancy); 7. Acute emergency; 8. Communication barriers; 9. Height < 145cm; 10. Follow-up failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First rescue analgesia time;Total consumption of sufentanil ; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score during rest and exercise, Ramsay sedation scale score, patient satisfaction score, first time out of bed, hospital stay, postoperative complications.; | — |
Countries
China
Contacts
Public ContactZhenglian Gao
Panzhihua Central Hospital
Outcome results
None listed