Percutaneous transforaminal endoscopic discectomy
Conditions
Interventions
Group C: control group:physiological saline + Dextrmetomidine
Group E1: 0.1 mg/kg esketamine:0.1 mg/kg esketamine + Dextrmetomidine
Group E2:0.2 mg/kg esketamine:0.2 mg/kg esketamine + Dextrmetomidine
Sponsors
The First Affiliated Hospital of Gannan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Conform to the indications of percutaneous transforaminal endoscopic surgery and consent to the surgery; 2. ASA I-II level, aged 18-60 years; 3. Informed of this study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients refuse to participate in this researcher; 2. Patients with major organ dysfunction; 3. Patients with severe hypertension and diabetes mellitus; 4. Allergic to dexmedetomidine and esketamine; 5. Patients with severe bradycardia and conduction block; 6. Patients with chronic pain, mental illness, alcohol or drug abuse history; 7. Long-term use of sedative or analgesic drugs; 8. Intracranial pressure or intraocular pressure increased; 9. BMI > 30 or < 18 kg/m2; 10. Patients with language and communication barriers; 11. Pregnant or lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nacotrend index;respiratory rate;tidal volume;blood pressure;heart rate;pulse oxygen saturation; | — |
Countries
China
Contacts
Public ContactWang Lifeng
The First Affiliated Hospital of Gannan Medical College
Outcome results
None listed