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Effect of fennel on cytokines in patients with hospital acquired pheumonia

Effect of fennel on cytokines in patients with hospital acquired pheumonia

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300068205
Enrollment
Unknown
Registered
2023-02-10
Start date
2023-02-10
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hospital aquired pheumonia

Interventions

experimental group:Hot compress with fennel
control group:Hot compress with kosher salt

Sponsors

The First Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Male or female subjects at least 18 years old; 2. Meeting the criteria for nosocomial infection: new infections occurring 48 hours after admission; 3. Chest X-ray or CT showing new or progressive infiltrating shadow, solid shadow or ground glass shadow; 4. Plus 2 or more of the following 5 clinical symptoms: (1) Fever, body temperature > 38 ?; (2) Purulent airway discharge; (3) Peripheral blood white blood cell count > 10 x 10^9/L or < 4 x 10^9/L; (4) A new cough, dyspnea or increased respiratory rate, or an aggravation of an existing cough, dyspnea or tachypnea; (5) Worsening of gas exchange (oxygenation index <= 200mmHg); 5. The subject or legal representative has been informed of the nature of the study, understands the protocol, is able to assure compliance, and signs the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients already had lower respiratory tract infection at admission and had not been cured after admission; 2. The original underlying lung disease, and the emerging lung shadow can not be ruled out as the progression of underlying disease; 3. Patients with acquired immune deficiency syndrome or active tuberculosis; 4. Patients admitted to hospital due to digestive diseases; 5. Patients undergoing other clinical trials whose data were not permitted for use in this study; 6. Pregnant or lactating.

Design outcomes

Primary

MeasureTime frame
Pneumonia severity index, PSI;All-cause mortality;cytokine;Clinical Pulmonary Infection score, CPIS ;

Secondary

MeasureTime frame
white blood cell count;diamine oxidase;C-reactive protine;Age;Arterial blood gas index;Mechanical ventilation use and exit rate, Incidence of gastrointestinal injury;

Countries

China

Contacts

Public ContactWan Dong

The First Affiliated Hospital of Chongqing Medical University

1589456887@qq.com+86 13996012837

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026