hospital aquired pheumonia
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male or female subjects at least 18 years old; 2. Meeting the criteria for nosocomial infection: new infections occurring 48 hours after admission; 3. Chest X-ray or CT showing new or progressive infiltrating shadow, solid shadow or ground glass shadow; 4. Plus 2 or more of the following 5 clinical symptoms: (1) Fever, body temperature > 38 ?; (2) Purulent airway discharge; (3) Peripheral blood white blood cell count > 10 x 10^9/L or < 4 x 10^9/L; (4) A new cough, dyspnea or increased respiratory rate, or an aggravation of an existing cough, dyspnea or tachypnea; (5) Worsening of gas exchange (oxygenation index <= 200mmHg); 5. The subject or legal representative has been informed of the nature of the study, understands the protocol, is able to assure compliance, and signs the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients already had lower respiratory tract infection at admission and had not been cured after admission; 2. The original underlying lung disease, and the emerging lung shadow can not be ruled out as the progression of underlying disease; 3. Patients with acquired immune deficiency syndrome or active tuberculosis; 4. Patients admitted to hospital due to digestive diseases; 5. Patients undergoing other clinical trials whose data were not permitted for use in this study; 6. Pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pneumonia severity index, PSI;All-cause mortality;cytokine;Clinical Pulmonary Infection score, CPIS ; | — |
Secondary
| Measure | Time frame |
|---|---|
| white blood cell count;diamine oxidase;C-reactive protine;Age;Arterial blood gas index;Mechanical ventilation use and exit rate, Incidence of gastrointestinal injury; | — |
Countries
China
Contacts
The First Affiliated Hospital of Chongqing Medical University