cancer related fatigue
Conditions
Interventions
Intervention group:Astragalus polysaccharides for injection+Paclitaxel for injection (albumin bound type) + carboplatin for injection
control group:placebo+Paclitaxel for injection (albumin bound type) + carboplatin for injection
Sponsors
Guanganmen Hospital, Chinese Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria (1) NSCLC patients with stage III-IV confirmed by pathology or cytology and unable to undergo surgical treatment; (2) Patients who plan to undergo initial chemotherapy; (3) Physical condition score ECOG 0-1; (4) There was no CRF in BFI evaluation; (5) The skin test of astragalus polysaccharide for injection was negative; (6) Age 18-75; (7) Estimated survival time = 3 months (8) Subjects have no major organ dysfunction.
Exclusion criteria
Exclusion criteria: Exclusion criteria (1) Patients with previous chemotherapy (2) Chemotherapy concurrent with radiotherapy, targeted therapy and immunotherapy (3) Evaluation of people with fatigue symptoms by BFI (4) People with a history of uncontrollable mental illness (5) People who are allergic to the study drug (6) Those who cannot understand and refuse to sign the informed consent form (7) Unable to cooperate with the meter data collector (8) Pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of CRF;CRF degree; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical symptoms (MDASI-LC);quality of life (EORTCQLQ-C30);kps score?ECOG score;immune markers (CD4, CD8, NK, etc.);hemoglobin;Neutrophils;PLT;ORR;DCR; | — |
Countries
China
Contacts
Public Contacthouwei
Guanganmen Hospital, Chinese Academy of Chinese Medical Sciences
Outcome results
None listed