Gastrointestinal cancer surgery and hip replacement
Conditions
Interventions
Gastrointestinal cancer surgery cyclopropofol group:cyclopropofol
Gastrointestinal cancer surgery propofol group:Propofol
Hip replacement cyclopropofol group:cyclopropofol
Hip replacement propofol group:Propofol
Sponsors
Affiliated Hospital of Yangzhou University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: The patients were of American Society of Anesthesiologists physical status I-?, aged 60-85 yr, with body mass index of 18-25kg/m2, who could independently complete preoperative cognitive function tests, and had no contraindications to epidural puncture
Exclusion criteria
Exclusion criteria: Patients allergic to egg and soy products, propofol, opioids and their antidote, combined with preoperative neuropsychiatric diseases, preoperative communication disorders due to coma, language disorders, severe illness, etc. Patients with severe disease (ASA > ?), severe liver dysfunction (Child-Pugh C) or severe renal dysfunction (Scr > 178 µmol /L), alcohol or drug abuse, preoperative MMSE score < 24, epidural puncture failure, and refused to provide informed consent due to other factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| inflammatory factor;cortisol;Quality of recovery;postoperative cognitive function;S100ß; | — |
Countries
China
Contacts
Public ContactYang Dawei
Affiliated Hospital of Yangzhou University
Outcome results
None listed