The relationship of postoperative lung injury with intestinal flora disorder

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300068183

Enrollment

Unknown

Registered

2023-02-09

Start date

2023-02-15

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative lung injury

Interventions

degree of postoperative lung injury:no

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients who were selected for lumbar intervertebral disc removal and internal fixation in prone position were both male and female Operation time over 2 hours Sign informed consent

Exclusion criteria

Exclusion criteria: Patients with COPD, asthma, chronic bronchitis, lung cancer and other lung diseases ,had lung infections within the last three months History of pulmonary surgery Severe anemia(<90g/L) Hypoxemia(SpO2<95%) Suffering from mental disorders (e.g. depression, anxiety and PTSD), autoimmune diseases(such as type 1 diabetes, rheumatoid arthritis, multiple sclerosis and psoriasis) or hereditary diseases (such as thalassemia, hereditary deafness and phenylketonuria) History of drug use Refusing to participate in experimental research

Design outcomes

Primary

Measure	Time frame
arterial blood gas analysis;alveolar lavage fluid of TNF-a?IL-1ß?IL-6?IL-8 ;Ang-2 and RAGE;intestinal microbiota composition and abundance;	—

Secondary

Measure	Time frame
vital signs;postoperative pulmonary complications;	—

Countries

China

Contacts

Public ContactWang Qingxiu

Shanghai East Hospital

qxw1123@126.com13310054121

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026