Comparison of the effects of ciprofol and etomidate on hemodynamics during induction of general anesthesia in elderly patients: a prospective randomized controlled double-blind trial

Comparison of the effects of ciprofol and etomidate on hemodynamics during induction of general anesthesia in elderly patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300068175

Enrollment

Unknown

Registered

2023-02-09

Start date

2023-04-24

Completion date

Unknown

Last updated

2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Ciprofol group:induced with intravenous ciprofol (0.2 mg/kg)

Etomidate group:induced with intravenous etomidate (0.3 mg/kg)

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. ASA grade I-II; 2. Aged >= 65 years, no gender limit, elective surgery patients; 3. BMI 18-30kg/m^2; 4. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Those who are allergic to or contraindicated to drugs used in this study, such as benzodiazepines, etomidate,opioids, ciprofol and their components; 2. Participated in other clinical trials within 4 weeks before operation; 3. Severe cardiovascular system, respiratory system, nervous system, liver and kidney diseases before operation; Patients with blood and metabolic diseases; 4. Patients with uncontrolled or poorly controlled hypertension; 5. Adrenocortical insufficiency, liver and kidney insufficiency; 6. Abuse of alcohol,benzodiazepines drugs or opioids; 7. Patients with expected difficult airway.

Design outcomes

Primary

Measure	Time frame
Changes of mean arterial pressure (MAP) during induction of general anesthesia;	—

Secondary

Measure	Time frame
Heart rate (HR) changes during induction of general anesthesia;Vital signs at different time points during induction of general anesthesia;Incidence of injection pain;Incidence of myoclonus;Use of vasoactive drugs;Incidence of cardiovascular adverse events;Bispectral index value; MAP under baseline MAP at different time points;AUC of MAP at different time points;	—

Countries

China

Contacts

Public ContactHu Bailong

The Affiliated Hospital of Guizhou Medical University

375896605@qq.com+86 151 8518 4309

Outcome results