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To determine the half-maximal effective concentration (EC50) of ropivacaine in different medication groups on the analgesic efficacy for the patient with ultrasound-guided supra inguinal fascia iliaca compartment block (FICB): a randomized, double-blind controlled trial.

To determine the half-maximal effective concentration (EC50) of ropivacaine in different medication groups on the analgesic efficacy for the patient with ultrasound-guided supra inguinal fascia iliaca compartment block (FICB): a randomized, double-blind controlled trial.

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300068169
Enrollment
Unknown
Registered
2023-02-09
Start date
2023-02-15
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Observation on analgesia of the patient with proximal femur fractures who accepted total hiparthroplasty

Interventions

Ropivacaine group:Various concentrations of ropivacaine with 20mL volume
low doses Dexmedetomidine + Ropivacaine group:Various concentrations of ropivacaine and Dexmedetomidine 0.2ug/kg with 20mL volume
moderate doses Dexmedetomidine + Ropivacaine group :Various concentrations of ropivacaine and Dexmedetomidine 0.6ug/kg with 20mL volume
high doses Dexmedetomidine + Ropivacaine group:Various concentrations of ropivacaine and Dexmedetomidine 1ug/kg with 20mL volume

Sponsors

Funing People's Hospital of Jiangsu Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 75 Years

Inclusion criteria

Inclusion criteria: Gender is not limited, ASA grade I-III, aged 50-75 years, body mass index (BMI) 20-29kg / ?. Patients with normal intelligence, ability to understand and willing to participate in this study, and willing to sign informed consent.

Exclusion criteria

Exclusion criteria: Patients with severe cardiopulmonary function, liver and kidney dysfunction; Patients with allergic history of related drugs;the patient was not able or willing to cooperate with testing and assessments; Patients with a long history of gastric ulcer and gas-trorrhagia; Patients cannot tolerate a nerve block; Patients with a contraindication for puncture;Patients with a long history of painful diseases; Patients with a history of drug or alcohol dependence; Contraindications for general anaesthesia; Patients with severe cardiopulmonary function, liver and kidney dysfunction; Patients with high blood pressure, diabetes, mental disorders and mental disorders.

Design outcomes

Primary

MeasureTime frame
VAS Scoring;EC50 by sequential approach;—

Secondary

MeasureTime frame
Demographic data;nerve block-related conditions;Resuscitation situations;Prognosis of the studied patients;Adverse effects;—

Countries

China

Contacts

Public ContactDekun Yin

Funing People's Hospital of Jiangsu Province

153761717@qq.com15805110243

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026