etomidate-induced myoclonus
Conditions
Interventions
Control group:Pre-injection of 10ml physiological saline
Observation group :pre-injection esketamine
Sponsors
Funing People's Hospital of Jiangsu Province
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patients are the first scheduled to undergo elective surgery under general anesthesia. Gender is not limited, ASA grade I-II, aged 20-55 years, body mass index (BMI) 22-28kg / ?. Patients with normal intelligence, ability to understand and willing to participate in this study, and willing to sign informed consent.
Exclusion criteria
Exclusion criteria: Patients with severe cardiopulmonary function, liver and kidney dysfunction. Patients have the history of psychiatric or neurological diseases.The patients had an upper airway infection during the 2 weeks prior to surgery.The patient has used analgesia or sedative in the preceding 24 h.Allergy to related drugs applied in the trial. Patients with history of alcohol or drug abuse. The patients had severe hypokalemia, ocular hypertension and intracranial hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency and severity of myoclonus after injection of etomidate.;Frequency and severity of withdrawal movements after injection of rocuronium.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic data;Time to onset of myoclonus after etomidate injection.;The incidence of total involuntary movements following etomidate and rocuronium administration.;the drug injection times;The occurrence of injection pain;Adverse effects; | — |
Countries
China
Contacts
Public ContactDekun Yin
Funing People's Hospital of Jiangsu Province
Outcome results
None listed