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Single cell sequencing analysis of cell heterogeneity and gene expression difference in lower respiratory tract of patients with pneumoconiosis

Single cell sequencing analysis of cell heterogeneity and gene expression difference in lower respiratory tract of patients with pneumoconiosis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300068165
Enrollment
Unknown
Registered
2023-02-09
Start date
2023-02-15
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pneumoconiosis

Interventions

Pneumoconiosis patients group:N/A
Healthy control group:N/A

Sponsors

The 920th Hospital of the Joint Logistics Support Force of the People's Liberation Army
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Pneumoconiosis Group: (1)Patients were diagnosed as pneumoconiosis according to GBZ70-2015/GBZ70-2008 Diagnostic Criteria for Occupational Pneumoconiosis (2) Agree to participate in the research and sign the informed consent; (3) Age =18 years old. Matched Group: (1)Patients who have no history of continuous exposure to dust throughout the year, and who are suspected to have non-pneumoconiosis by imaging examinations, but need to be confirmed by bronchoscopy; (2) Agree to participate in the research and sign the informed consent; (3) Age =18 years old.

Exclusion criteria

Exclusion criteria: Pneumoconiosis Group: (1) Clinically diagnosed patients with lung cancer, bronchial asthma, bronchiectasis, pneumonia, tuberculosis and other lung diseases; (2) Clinically diagnosed inflammatory bowel disease, type 1 diabetes and other metabolic immune diseases; (3) Persons suffering from infectious diseases such as AIDS; (4) Used non-resident anti-inflammatory drugs in the past 3 months; (5) Currently taking glucocorticoids or immunosuppressants for more than 2 weeks; (6) The clinician judged that tracheoscopy was not suitable. Matched Group: Exclusion criteria were the same as those of pneumoconiosis group.

Design outcomes

Primary

MeasureTime frame
cell grouping;Gene expression difference;

Countries

China

Contacts

Public ContactLi Shaoying

The 920th Hospital of the Joint Logistics Support Force of the People's Liberation Army

1024942115@qq.com13320507969

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026