herpes zoster (HZ)
Conditions
Interventions
Experimental group:Continuous paravertebral nerve block
Control group:Repetitive paravertebral nerve block
Sponsors
The First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Meet the HZ diagnostic criteria and VAS score >=40 points at treatment; 2. Aged 18-85 years; 3. Herpes lesions range from thoracic spinal nerve innervation area (T1-T12), involving no more than 4 segments, and the course of disease is 30-90 days; 4. Had not received nerve block or other minimally invasive interventional therapy before enrollment; 5. Agree to participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe cardiopulmonary insufficiency, severe liver and kidney insufficiency and combined with blood system diseases; 2. There is skin damage or local infection at the puncture site; 3. Diabetic patients with poor blood glucose control (fasting blood glucose >=10.0mmol/L); 4. Patients with abnormal coagulation function; 5. Patients who are allergic to local anesthetics and other drugs used in this study or are not suitable for nerve block; 6. Pregnant and lactating patients; 7. Patients with mental illness or cognitive dysfunction who cannot fully understand the research scale; 8. Patients with a history of sleep disorders; 9. Patients with a history of opioid addiction or abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain degree 1 month after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postherpetic neuralgia (PHN) after 2 months (duration > 90 days, VAS > 30);Visual analogue scale score (VAS);Proportion of patients with complete pain relief (VAS<=10), good sleep quality (PSQI<=10), no anxiety (PHQ-9<=4), and no depression (GAD-7<=4);Dosage of analgesic drugs and remedial drugs;Occurrence of adverse reactions and serious adverse events;Pittsburgh Sleep Quality Index Score;The 7-item Generalized Anxiety Disorder Scale Score;Patient Health Questionnaire-9, PHQ-9; | — |
Countries
China
Contacts
Public ContactGu Nan
The First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed