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Association of vitamin B12,folic acid and homocysteine with cognitive dysfunction and white matter lesion in cerebral small vessel disease:a case-control study

Association of vitamin B12,folic acid and homocysteine with cognitive dysfunction and white matter lesion in cerebral small vessel disease:a case-control study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300068150
Enrollment
Unknown
Registered
2023-02-08
Start date
2023-02-10
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral small vessel disease

Interventions

Group of cerebral small vessel disease:None

Sponsors

Jincheng People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1)Aged 50-80 years old;(2)There are no metal objects in the body,and participants can cooperate with the completion of nuclear magnetic inspection(3)Participants who meet the criteria of STRIVE(Standards for reporting vascular changes on neuroimaging);(4)Inform the patients and their families of this study. The patients and their families are willing to cooperate with relevant examinations and sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1)Head injury, encephalitis, epilepsy, Parkinson's disease, Alzheimer's disease, frontotemporal dementia, schizophrenia and other neurological or psychiatric diseases; (2) Severe liver and kidney dysfunction or other systemic diseases; (3)Alcohol or drug dependence; Used oral vitamin supplements;(4)Obvious stenosis of intracranial or extracranial arterial stenosis(TCD or MRA proved that the degree of stenosis was = 50%);(5)Those who cannot perform the clinical evaluation (such as those who cannot cooperate due to blindness, hearing impairment, aphasia, severe dementia and other reasons).

Design outcomes

Primary

MeasureTime frame
white matter lesion;vitamin B12;folic acid;homocysteine;Mini-Mental State Examination (MMSE);Montreal Cognitive Assessment (MoCA);

Countries

China

Contacts

Public ContactHuimin Li

Jincheng People's Hospital

714728386@qq.com18734618671

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026