Effect of macrophage polarization on septation formation and postoperative recurrence in patients with chronic subdural hematoma, a prospective, exploratory study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300068129

Enrollment

Unknown

Registered

2023-02-08

Start date

2023-02-10

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic subdural hematoma

Interventions

Separate Group:N/A

Simple Hematoma Group:N/A

Eligibility

Sex/Gender

All

Age

50 Years to 100 Years

Inclusion criteria

Inclusion criteria: Over 50 years old Combining medical history, clinical symptoms, and imaging examinations (CT or MRI), the diagnosis of CSDH is clear. Hard channel drilling and drainage as a surgical intervention. The patient received examination and treatment, and the compliance was good. Sign the informed consent form. Follow-up for more than 3 months after discharge.

Exclusion criteria

Exclusion criteria: Take any anticoagulant medication before or during treatment. Subdural hematoma caused by intracranial vascular disease (aneurysm, cerebral vascular malformation, etc.). Recurrent chronic subdural hematoma. Those with serious diseases of other important organs. Patients undergoing craniotomy.

Design outcomes

Primary

Measure	Time frame
M1/M2 macrophage number ratio;CD68;CD86;iNOS;CD206;Ym1;Arginase-1;	—

Countries

China

Contacts

Public ContactChen Yuan

The Second Affiliated Hospital of Chongqing Medical University

chengyuan023@aliyun.com13708329653

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026