Post-traumatic elbow stiffness
Conditions
Interventions
Group 1:Intravenous infusion of 100mL normal saline+2g tranexamic acid mixture within 15~30 min before skin incision
Group 2:Intravenous infusion of 100mL normal saline within 15~30 min before skin incision
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Non-surgical treatment for at least 6 months did not restore the required arc of motion (=18 years; 3. Elbow stiffness caused by ectopic ossification, which is mature.
Exclusion criteria
Exclusion criteria: 1. Known allergy to tranexamic acid; 2. Known bleeding disorders (e.g., hemophilia); 3. Concomitant severe comorbidities (e.g., kidney failure, severe lung disease, myocardial infarction, coronary artery disease, myocardial infarction, history of thrombosis); 4. Patients with abnormal preoperative inflammatory indexes (CRP>10 mg/L); 5. Patients with abnormal preoperative fibrinolysis indexes (FDP>5mg/L or D-dimer >1.0mg/L); 6. Patients at high risk of thrombosis (including atrial fibrillation, pacemaker and stent implantation); 7. Patients with combined burns or central nervous system trauma or ectopic ossification; 8. Patients could not return to the hospital for follow-up after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the recurrence of heterotopic ossification; | — |
Secondary
| Measure | Time frame |
|---|---|
| function score of elbow joint valued by Mayo Elbow Performance Score (MEPS) ;elbow ROM;C-reactive protein;ESR;IL-6;IL-1ß;IL-13; | — |
Countries
China
Contacts
Public ContactCui Haomin
Shanghai Sixth People's Hospital
Outcome results
None listed