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The role of urinary HBP in high-grade VUR-induced kidney injury and its clinical value as a novel marker of kidney injury

The role of urinary HBP in high-grade VUR-induced kidney injury and its clinical value as a novel marker of kidney injury

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300068096
Enrollment
Unknown
Registered
2023-02-07
Start date
2023-03-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vesicoureteral-reflux

Interventions

conservative group:N/A
healthy control group:N/A

Sponsors

Xiamen Hospital, Affiliated Pediatric Hospital of Fudan University; Xiamen Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
0.1 Years to 14 Years

Inclusion criteria

Inclusion criteria: 1. VUR was diagnosed by VCUG imaging examination, and classified into five categories according to the International Reflux Commission; 99mTc-DMSA renal static imaging examination has been improved to determine the existence and severity of renal scar; 2. Parents or legal guardians of children have written informed consent, good compliance, regular review, and follow-up. 3. Age <=14 years old.

Exclusion criteria

Exclusion criteria: 1. Secondary Vul caused by other reasons, such as neurogenic bladder, posterior urethral valve, duplication kidney, etc.; 2. Suffering from other diseases, such as acute and chronic kidney diseases, urinary calculi, narrow ureteropelvic junction, etc.; 3. Those who did not receive the planned imaging examination or did not collect samples at the first evaluation.

Design outcomes

Primary

MeasureTime frame
Urine HBP;

Secondary

MeasureTime frame
Blood HBP;Cystatin C;Blood creatinine;

Countries

China

Contacts

Public ContactZhou wei

Xiamen Hospital, Affiliated Pediatric Hospital of Fudan University; Xiamen Children's Hospital

etyy6161@126.com+86 178 5015 6154

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026