post-stroke aphasia
Conditions
Interventions
Experimental group:continuous theta-burst stimulation combined intermittent theta-burst stimulation
control group:sham continuous theta-burst stimulation combined sham intermittent theta-burst stimulation
Sponsors
China Rehabilitation Research Center
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. In accordance With the Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke and Guidelines for the Management of Acute Ischemic Stroke Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association of diagnostic criteria for ischemic or hemorrhagic stroke, lesions in the left hemisphere, course of disease 2-8 weeks; 2. Meeting the diagnostic criteria for aphasia, WAB's aphasia quotient was less than 93.8; 3. First onset or with a history of stroke without apparent sequelae; 4. Age 35-75 years old; 5. Normal language function before onset, native Chinese, primary school education or above; 6. Patients and their families understand the trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Aphasia caused by brain tumor, Parkinson's syndrome, motor neurone disease and other neurological diseases or brain trauma; 2. There are metal foreign bodies or any implanted electronic equipment in the body, there are MRI scanning contraindications such as claustrophobia, and TMS treatment contraindications; 3. A history of epilepsy (at least 2 uninduced seizures with an interval of more than 24 hours, or seizures within the past 12 months); 4. Patients with severe heart, lung, liver, kidney and other systemic diseases that cannot be controlled by conventional drugs; 5. Patients with severe dysarthria, cognitive impairment, auditory and visual impairment, severe depression, anxiety, etc., who were unable to cooperate with the test; 6. A history of alcohol and drug abuse; 7. women who are pregnant or planning to become pregnant; 8. Patients who had received transcranial magnetic stimulation in the previous 3 months; 9. Participants in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Aphasia Battery; | — |
Secondary
| Measure | Time frame |
|---|---|
| BDAE classification of aphasia severity;Western Aphasia Battery; | — |
Countries
China
Contacts
Public ContactJingdu Zhao
China Rehabilitation Research Center
Outcome results
None listed