postoperative delirium
Conditions
Interventions
insulin group:intranasal insulin administration
placebo group:intranasal normal saline administration
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
65 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1. The patient's age >=65 years; 2. ASA grade I-III patients undergoing joint replacement under lumbar anesthesia; 3. Able to communicate with researchers and complete the evaluation of relevant scales; 4. Informed consent of patients and their families to participate in the study.
Exclusion criteria
Exclusion criteria: 1. ASA grade of patients exceeded grade III; 2. The patient has a prior psychiatric or neurological disease (e.g., intracranial tumor); 3. Have undergone surgery within the past 12 months; 4. Patients take warfarin and other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| insulin;Glucose;Postoperative delirium, POD;osteocalcin; | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF-a;brain derived neurotrophic factor, BDNF;Amyloid-ß;vitamin D3;deep venous thrombosis;lactate;vitamin K; | — |
Countries
China
Contacts
Public ContactOu Yangwen
The Third Xiangya Hospital of Central South University
Outcome results
None listed