Post-stroke cognitive impairment
Conditions
Interventions
Low-dose intervention group :Low-dose iTBS+conventional rehabilitation
High-dose intervention group:High-dose iTBS+conventional rehabilitation
sham group:sham iTBS+conventional rehabilitation
Sponsors
china rehabilitation research center
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 35 to 75 years. 2. First stroke, duration of illness 4 weeks to 12 months. 3. Stroke site located on the cerebral curtain. 4. right sharp hand. 5. stable vital signs and no progressive neurological symptoms. 6. meeting the diagnostic criteria in the Expert Consensus on Management of Cognitive Impairment after Stroke 2021, with the following conditions being met: (1) dysfunction in at least one of the following 5 areas: executive function, attention, memory, language ability, and visuospatial ability; (2) ability to cooperate in completing MoCA with a MoCA score = 10. 7. Meeting the diagnostic criteria for stroke in the Diagnostic Essentials of Various Major Cerebrovascular Diseases in China 2019. 8. Patients or family members were informed of the examination and treatment procedures of this study.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to TMS or fMRI, such as intracranial metal, epilepsy, etc. 2. History of drug or alcohol dependence, other psychiatric disorders, or current comorbid major depression/anxiety disorder. 3. Significant cognitive dysfunction prior to stroke. 4. Patients with a combination of severe aphasia, visual and hearing impairment, unstable arrhythmias or other serious physical conditions that prevent them from cooperating with the completion of cognitive assessment or treatment. 5. No previous rTMS intervention within 6 months prior to receiving treatment. 6. Women who are pregnant. 7. Patients are participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal cognitive assessment scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-mental state assessment scale;Wechsler adult intelligence scale;Wechsler Memory Scale; | — |
Countries
China
Contacts
Public ContactZhang Hao
China rehabilitation research center
Outcome results
None listed